The Gate Theory of Pain Revisited: Modeling Different Pain Conditions with a Parsimonious Neurocomputational Model

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The Gate Theory of Pain Revisited: Modeling Different Pain Conditions with a Parsimonious Neurocomputational Model

The gate control theory of pain proposed by Melzack and Wall in 1965 is revisited through two mechanisms of neuronal regulation: NMDA synaptic plasticity and intrinsic plasticity. The Melzack and Wall circuit was slightly modified by using strictly excitatory nociceptive afferents (in the original arrangement, nociceptive afferents were considered excitatory when they project to central transmi...

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Gate Control Theory of Pain

The gate control theory of pain, put forward by Ronald Melzack (a Canadian psychologist) and Patrick David Wall (a British physician) in 1962, and again in 1965, is the idea that the perception of physical pain is not a direct result of activation of nociceptors, but instead is modulated by interaction between different neurons, both pain-transmitting and non-pain-transmitting. The theory asser...

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The gate control theory of pain.

For example, you will probably be aware that there are times when, even though you have pain, you are only dimly aware of it. This may happen when you are really engrossed in doing something interesting or having to face a situation which demands all of your attention. A very good example of this is the stories you might have heard about wounded soldiers who, despite being seriously injured, wi...

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ژورنال

عنوان ژورنال: Neural Plasticity

سال: 2016

ISSN: 2090-5904,1687-5443

DOI: 10.1155/2016/4131395